Semax
Semax is a synthetic heptapeptide analogue of ACTH(4-7). Originally developed in Russia, it has been extensively researched for cognitive enhancement, neuroprotection, and BDNF upregulation. Research demonstrates enhanced memory, focus, and neuroplasticity.
Semax — Scientific Overview
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analogue of ACTH(4-7) with C-terminal Pro-Gly-Pro extension. Its primary mechanism involves upregulation of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptor, promoting neuroplasticity and neuronal survival.
Semax activates melanocortin receptors, modulates dopaminergic and serotonergic neurotransmission in the hippocampus and prefrontal cortex, reduces neuroinflammatory markers (IL-1β, IL-6), increases VEGF for cerebrovascular support, and promotes BDNF/TrkB-mediated synaptic strengthening. Intranasal administration delivers it to the CNS via olfactory pathways.
25+ years of Russian and Ukrainian clinical research documents: significant cognitive enhancement in healthy subjects, accelerated stroke recovery (registered pharmaceutical in Russia), neuroprotection in ischemia models, improvement in attention disorders, and anxiolytic effects without sedation.
Store lyophilized at -20°C. Reconstituted solution sensitive to temperature — stable 2–4 weeks at 2–8°C. Protect from light.
Related Compounds
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