Selank
Selank is a synthetic analogue of the human tetrapeptide tuftsin. Research examines its anxiolytic, nootropic, and immunomodulatory properties. Unlike traditional anxiolytics, it does not appear to cause sedation, tolerance, or dependence in research models.
Selank — Scientific Overview
Selank is a synthetic heptapeptide analogue of the human immune peptide tuftsin (Thr-Lys-Pro-Arg), extended with Gly-Gln-Pro for stability. It modulates GABA-A receptor function, increases BDNF expression, and regulates serotonin and dopamine metabolism in key brain regions.
Unlike classical benzodiazepines, Selank's anxiolytic effects occur without sedation, muscle relaxation, or dependency through a GABA-A modulatory mechanism distinct from benzodiazepine binding sites. It also increases BDNF expression promoting neuroplasticity and has documented immunomodulatory effects through tuftsin-like receptor interactions.
Published Russian research documents: significant anxiolytic effects equivalent to benzodiazepines in anxiety models without sedation or tolerance development; nootropic effects including improved memory consolidation and attention; immune modulation with increased phagocytic activity; and antiviral properties in influenza and herpes models.
Store lyophilized at -20°C. Reconstituted solution stable 28 days at 2–8°C. Protect from light.
Related Compounds
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