PE-22-28
PE-22-28 is a synthetic peptide fragment of spadin, itself derived from the TREK-1 potassium channel propeptide. Research has demonstrated rapid antidepressant effects in animal models, acting through a mechanism distinct from classical antidepressants with a notably fast onset of action.
PE-22-28 — Scientific Overview
PE-22-28 is a synthetic hexapeptide fragment of spadin, derived from the propeptide of TREK-1 (TWIK-related potassium channel-1). It acts as an antagonist/modulator of the TREK-1 potassium channel — a mechanosensitive, thermosensitive background K⁺ channel expressed in hippocampal neurons.
TREK-1 channel blockade depolarizes neurons and enhances serotonergic neurotransmission by preventing the hyperpolarizing effect that reduces serotonin neuron firing. This mechanism is distinct from SSRIs (which block serotonin reuptake) and produces rapid antidepressant effects in animal models — with onset within hours rather than weeks.
PE-22-28 demonstrates antidepressant effects in forced swim test and tail suspension test within 4–24 hours of administration. Research shows activation of hippocampal neurogenesis, normalization of BDNF expression, and no anxiogenic effects. The rapid onset mechanism positions it as a subject of intense pharmacological research.
Store lyophilized at -20°C. Reconstituted solution stable 14 days at 2–8°C. Bacteriostatic water for reconstitution.
Related Compounds
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