Dihexa
Dihexa is a potent nootropic peptide derived from angiotensin IV. Research has shown it to be several orders of magnitude more potent than BDNF in promoting new synapse formation. Studies have examined its effects on cognitive deficits and neurodegenerative conditions.
Dihexa — Scientific Overview
Dihexa (N-hexanoic-Tyr-Ile-6-aminohexanoic amide) is derived from angiotensin IV and functions as a high-affinity ligand for hepatocyte growth factor receptor (HGFR/c-Met). HGF/c-Met signaling promotes synaptogenesis — the formation of new synaptic connections between neurons.
HGFR activation triggers downstream signaling cascades that promote dendritic spine formation, presynaptic bouton development, and stabilization of new synaptic connections. Published research suggests Dihexa is 10⁷ times more potent than BDNF in promoting synapse formation in cell models — extraordinary potency that drives intense scientific interest.
Preclinical research demonstrates: reversal of scopolamine-induced cognitive deficits, improvement in spatial learning in aged rats (equivalent to young-adult performance), protection against neurodegeneration in Parkinson's models, and enhanced social cognition. Primary research focus is cognitive rescue.
Store lyophilized at -20°C. Reconstituted solution stable 14 days at 2–8°C. Can also be formulated for transdermal delivery research. Bacteriostatic water for parenteral reconstitution.
Related Compounds
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